Depression is one of the leading causes of morbidity in the world and significantly affects the lives of people suffering from it. The exact cause of depression has not been established and it is believed to be a complex play between various social, biological, environmental, personal factors. A relatively rare but distinct cause includes pharmacological agents.

In this case report, we describe the case of a 17-year-old girl who developed depression with psychotic symptoms on two occasions, both preceded by a history of Isotretinoin use. She was admitted and treated with anti-psychotics and psychotherapy with significant improvement in her mental state.

There is no global consensus and direct scientific evidence establishing causality but many case reports are present in medical literature showing association between depression and Isotretinoin use. Therefore, it is important for clinicians to exercise caution when prescribing Isotretinoin to vulnerable groups.

First Page


Last Page


Conflict of Interest



Adverse Drug Reaction, Depression, Isotretinoin, Psychosis, Psychiatry

Word Count


Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Cover Page Footnote




To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.