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Author ORCID Identifier

https://orcid.org/0009-0003-2368-1697

https://orcid.org/0009-0002-3745-8667

Corresponding Author

B.Dharani

E-mail: doctordharanibhaskaran@gmail.com

Address: No-110/11 Kailash Sector, Kaladipet, Thiruvottiyur, Chennai-19.

Contact no: +91-8610263796

ORCID ID: 0009-0003-2368-1697

Abstract

Objectives: Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by persistent hyperglycemia resulting from insulin resistance and inadequate insulin production. A critical aspect of T2DM is its microvascular complications, notably diabetic nephropathy, which progresses from microalbuminuria to overt proteinuria, and eventually End-Stage Renal Disease (ESRD). Inflammation-induced endothelial dysfunction is a key factor in the progression of diabetic nephropathy. The neutrophil-to-lymphocyte ratio (NLR) is an easily measurable marker derived from routine leukocyte analysis, reflecting systemic inflammation. Despite the known association between chronic inflammation and diabetic nephropathy, studies exploring this relationship remain limited. This study aims to investigate the correlation between urine albumin levels and the NLR in patients with T2DM.

Material & Methods: This cross-sectional pilot study, approved by IEC, examined 150 uncomplicated T2DM patients at a Chennai hospital over six months. Urine albumin and NLR were measured, and data analyzed using Pearson's correlation in SPSS.

Results: A strong positive correlation was observed between urine albumin levels and NLR in individuals with T2DM, with a r-value of 0.7.

Conclusions: This study finds a significant link between elevated NLR and increased urine albumin levels in T2DM. This finding suggests that chronic inflammation in T2DM contributes to the development of albuminuria, which may progress to Diabetic Kidney Disease (DKD).

Publication Date

Winter 1-19-2024

Publisher

JSS Academy of Higher Education & Research

Conflict of Interest

The authors have no conflicts of interest to disclose regarding this article.

Keywords

Urine Albumin, Type 2 Diabetes Mellitus, NLR, Neutrophil to Lymphocyte Ratio, Diabetic Nephropathy, Diabetic Kidney Disease, Albuminuria, Inflammatory marker

Word Count

2651

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

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