Author ORCID Identifier
Abstract
Background: The relationship between COVID-19 vaccination and the incidence of myocardial infarction remains a topic of debate. The study aimed to analyze the demographic, clinical, and outcome characteristics of MI patients post-vaccination in India, focusing on differences between Covishield and Covaxin recipients.
Methods: The retrospective observational study included 303 MI patients admitted to a tertiary care center. Data were collected on demographics, comorbidities, vaccination status, ICU admissions, and outcomes. The Charlson Comorbidity Index (CCI) was used to assess disease severity. Statistical analyses evaluated the associations between vaccination status, clinical parameters, and mortality.
Results: Among the study population, 74.3% were males, and 32.7% were aged 51–60 years, reflecting the typical Indian MI demographic. Covishield was the predominant vaccine received (80.9%), followed by Covaxin (15.2%), and 4.0% were unvaccinated. No significant differences were observed in CCI scores across vaccination groups. However, the mean CCI was significantly
higher in deceased patients than in survivors. ICU admission rates were higher in Covishield recipients (53.1%) than in Covaxin recipients (41.3%), but this difference was not statistically significant. Mortality rates were slightly higher in the Covishield group (11.1%) compared to the Covaxin group (8.9%), although this difference wasn't significant. ICU management was associated with better survival rates compared to ward care.
Conclusion: The study contributes to the growing body of evidence supporting the cardiovascular safety of COVID-19 vaccines. While vaccination wasn't significantly associated with increased MI risk or mortality, higher comorbidity burdens were linked to worse outcomes.
Publication Date
2025
Publisher
JSS Academy of Higher Education & Research
Keywords
SARS-CoV-2, COVID-19, Covishield, Covaxin, Acute myocardial infarction
Word Count
3982
Recommended Citation
Pinnam HS, Madhavan H, Harshitha J, Patil V, Tiwari H, Kumthekar IA, Sri Mounya J.
Myocardial Infarction Trends Following COVID-19 Vaccination: A Retrospective Investigation From India.
Digital Journal of Clinical Medicine.
2025;
7(1):
-.
doi:
https://doi.org/10.55691/2582-3868.1227
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