Undifferentiated Embryonal Sarcoma of Liver in a child : a case report

Authors

Neha Devendra Bhongale, Topiwala National Medical college & B.Y.L. Nair Charitable Hospital, MumbaiFollow
Sumeet Baheti, Topiwala National Medical College & B.Y.L. Nair charitable Hospital, MumbaiFollow
Poonam Wade, TNMC and BYL Nair Ch hospital, MumbaiFollow
Omkar khandkar, Topiwala national Medical College & B.Y.L.Nair Charitable Hospital, MumbaiFollow
Meenakshi Balasbramanian, Topiwala National Medical College & B.Y.L. Nair Charitable Hospital, MumbaiFollow

Author ORCID Identifier

https://orcid.org/0009-0008-8372-2004

Corresponding Author

Neha Bhongale

drnehadb01@gmail.com

Abstract

Background: Undifferentiated Embryonal Sarcoma of liver (UESL) is a rare malignancy of liver originating from primary mesenchymal tissue with overall poor prognosis. Around 220 pediatric cases of UESL have been reported in the literature. The lack of characteristic clinical manifestations, laboratory tests and imaging studies pose a diagnostic challenge and the preoperative misdiagnosis rate is high. Historically, treatment was limited to surgical resection with poor survival rate. In recent times, combination of chemotherapy and surgical resection has improved survival.

Case Presentation: We report a case of undifferentiated embryonal sarcoma of liver in a 6 years old boy who presented with complain of fever, right sided abdominal mass with intermittent abdominal pain of 1 month duration. On examination, child was under-weight and had fever, anemia and massive hepatomegaly.

Management: Radio imaging of abdomen revealed a heterogeneous mass in right hepatic lobe with differential diagnosis of hamartoma, hepatoblastoma or UESL. He had normal liver function tests, serum alpha-fetoprotein (AFP) level. Diagnosis of UESL was confirmed on histology and immunohistochemistry features on liver biopsy.

Due to rapidly growing tumor, hepatic arterial embolization was done. Child received chemotherapy followed by surgical resection. Post surgical resection child had gained weight and was doing well on his 3 months follow up.

Conclusion: UESL should be considered in differential diagnosis in a young child with rapidly growing liver mass especially with normal serum AFP levels and the lesion shows mixed cystic and solid components on radio-imaging. Multimodal management is required for better outcome.

Publication Date

Fall 2025

Publisher

JSS Academy of Higher Education & Research

Conflict of Interest

None

Keywords

Abdominal mass, hepatic mass, Undifferentiated Embryonal Sarcoma, UESL, pediatric liver malignancy

Word Count

1300

Recommended Citation

Bhongale ND, Baheti S, Wade P, khandkar O, Balasbramanian M. Undifferentiated Embryonal Sarcoma of Liver in a child : a case report. Digital Journal of Clinical Medicine. 2025; 7(3): -. doi: https://doi.org/10.55691/2582-3868.1257

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