Author ORCID Identifier
http;//orcid.org/0009-0008-2037-3708
Abstract
Tuberculosis is a chronic pulmonary infectious disease caused by Mycobacterium tuberculosis and can affect other parts of the body such as bones, brain, and lymph nodes (extra pulmonary Tb). Statins, primarily used for hyperlipidemia, have demonstrated anti-inflammatory and immunomodulatory properties that may help prevent and manage TB. They inhibit HMG-CoA reductase, reduce cholesterol synthesis and interfere with phagocytosis crucial for TB infection. Given the rise in resistance to first-line anti-tubercular therapies, Statins have shown promise as adjunctive agents by potentially shortening treatment duration, reducing adverse effects, and improving outcomes, particularly in immunocompromised and diabetic patients. Based on these findings, Statins may be considered as second-line anti-TB drugs.
Publication Date
Summer 6-21-2025
Publisher
JSS Academy of Higher Education & Research
Conflict of Interest
The authors (Mehwish Hanif, Ayesha, Laiba zahoor) have explicitly stated in their declarations that they have not received or given any unauthorized assistance, and there is no plagiarized material in their work.They also confirm that the paper is free from undisclosed conflicts of interest. Therefore, no conflicts of interest are declared in this document.
Keywords
Statins; Tuberculosis; Adjuvant Therapy; Drug Repurposing; Immunomodulation; Cholesterol Synthesis; Mycobacterium tuberculosis
Word Count
322
Recommended Citation
Hanif M, Tariq A, Zahoor L.
Potential Effect of Statins as Adjuvant Anti‑Tuberculosis Agents: A Short Communication.
Digital Journal of Clinical Medicine.
2025;
7(4):
-.
doi:
https://doi.org/10.55691/2582-3868.1253
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Cover Page Footnote
Corresponding Author: Mehwish Hanif ,Amna Inayat Medical College
Included in
Diseases Commons, Health Information Technology Commons, Medical Education Commons, Medical Sciences Commons, Medical Specialties Commons, Mental and Social Health Commons, Psychiatry and Psychology Commons, Public Health Education and Promotion Commons
Comments
This Letter To Editor explores the potential effect of statins as adjuvant anti-tuberculosis drug, highlighting their anti-inflammatory and immunomodulatory properties that may shorten treatment duration and reduce adverse effects in TB patients.