Author ORCID Identifier
https://orcid.org/0009-0002-9087-7158
Abstract
Background: Facial hyperpigmentation, encompassing melasma, post-inflammatory hyperpigmentation (PIH), and solar lentigines, is common and psychosocially impactful; depigmenting agents may be less effective without concurrent photoprotection, so this review evaluates the synergistic potential of combining depigmentation serums with UV protection. Methods: A comprehensive PubMed review assessed mechanisms, clinical efficacy, and safety of hydroquinone, α‑arbutin, vitamin C, niacinamide, and piperine when paired with broad‑spectrum photoprotection, analyzing clinical trials and comparative studies on combination regimens. Results: Combining depigmenting agents with UV protection improves outcomes, with multi‑ingredient serums showing efficacy comparable to 4% hydroquinone but better tolerance, plus measurable gains in melanin/erythema indices, hydration, and satisfaction. Conclusion: Dual‑modality therapy that integrates topical depigmenting agents with daily UV protection is effective for treatment and prevention, addressing melanin overproduction and UV triggers; standardized trials should optimize formulations and long‑term protocols.
Publication Date
2025
Publisher
JSS Academy of Higher Education & Research
Conflict of Interest
Conflicts of Interest: The authors declare no conflicts of interest.
Keywords
Hyperpigmentation, Melasma, Post-inflammatory hyperpigmentation, Depigmentation serum, UV protection
Word Count
2076
Recommended Citation
darji j mr, patel s Ms, kansara v Ms, shukla h Mr.
Combined Efficacy of Topical Depigmentation Serum and UV Protection in Facial Hyperpigmentation: A Comprehensive Review.
Digital Journal of Clinical Medicine.
2025;
8(2):
-.
doi:
https://doi.org/10.55691/2582-3868.1283
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.