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International Journal of Health and Allied Sciences

Nivya Jimmy, Intern, Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysore-15, Karnataka, India.
Shahal Sidheque, Intern, Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysore-15, Karnataka, India.
Meghana Upadhya, Intern, Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysore-15, Karnataka, India.
Jesslyn Maria Jaison, Intern, Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysore-15, Karnataka, India.
Harsha Sundaramurthy, Professor & Head, Dept. of Neurology, JSS Medical College & Hospital, JSS Academy of Higher Education & Research, Mysuru
Nemichandra Siddanakatte Chandrasekhar, Associate Professor, Dept. of Neurology, JSS Medical College & Hospital, JSS Academy of Higher Education & Research, Mysuru
Shasthara Paneyala, Assistant Professor, Dept. of Neurology, JSS Medical College & Hospital, JSS Academy of Higher Education & Research, Mysuru
Madhan Ramesh, Professor, Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysore-15, Karnataka, India
Jehath Syed, Research Scholar, Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysore-15, Karnataka, India
Sri Harsha Chalasani, Assistant Professor, Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysore-15, Karnataka, IndiaFollow

Abstract

Background: Patient-Reported Outcome Measures (PROMs) play a critical role in improving patient engagement in therapy, symptom assessment, functional status, psychological well-being, and health-related quality of life (HRQoL) in neurological patient care. In addition, PROMs provide valuable insights for evaluating the effectiveness of interventions, comparing patient and organizational outcomes, and generating new information.

Objective: This study aimed to assess patient-reported outcomes using the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) and the EQ -5D-5L in patients with neurological disorders.

Methods: A six-month hospital-based observational cohort study was conducted in a South Indian tertiary care hospital, enrolling patients diagnosed with various neurological diseases. Standardized questionnaires, NDDI-E (for depression and suicidality screening in epilepsy), and EQ-5D-5L (for overall HRQoL assessment) were used to capture patient-reported outcome measures. Data analysis was performed categorically and is presented as n (%).

Results: NDDI-E and EQ-5D-5L questionnaires were administered to 310 patients. Among 82 people with epilepsy assessed using the NDDI-E, 19.51% were identified as having depression, and 10.98% had positive suicidal screening. The remaining 228 patients with other neurological disorders completed the EQ-5D-5L, with 70% reporting no problems in walking, 68% in self-care, and approximately 12.5% experiencing extreme anxiety. Various EQ-5D-5L health states were detected, with the most frequent being 22222, indicating slight limitations in all domains. A perfect health state, denoted by a score of 11111, was reported by 20 participants.

Conclusion: The results support the feasibility of using the EQ -5D-5L in neurological practice to optimize patient-centered care. The NDDI-E enables rapid detection and improved treatment of depression and suicidality in patients with epilepsy.

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